The probability that complex enzyme kinetic curves can be caused by activators or inhibitors

The probability that complex enzyme kinetic curves can be caused by activators of inhibitors.

Numerous chemical compounds are known that alter the rate of conversion of substrates into products in enzyme-catalysed reactions by interacting with the enzyme rather than substrates. Where this takes place in such a way that the effect is reversible on removing the compound, say by dialysis, and where the compound is unchanged chemically by the enzyme system, we refer to such a compound as a ...

Effect of Activators and Inhibitors on Lactase Activities to Determine its Kinetic Model

Editorial Comment Can Plasminogen Activators Be Improved?

T he widespread application of plasminogen activators in the treatment of myocardial infarction has resulted in a significant reduction in mortality.",2 Most patients have been treated with two very different drugs: streptokinase, a bacterial protein that is the product of fermentation technology dating from the 1930s, and recombinant tissue-type plasminogen activator (rt-PA), a human protein t...

A crystalline enzyme that cleaves homoserine and cystathionine. III. Coenzyme resolution, activators, and inhibitors.

The authors reported earlier (1) that the crystalline homoaerine deaminase-cystathionase prepared from rat livers contained pyridoxal-5-phosphate as the prosthetic group, and that the bound pyridoxal-5-phosphate is responsible for the absorption maximum at 427 rnp. The present paper deals with resolution of the enzyme into pyridoxal-5-P and catalytically inactive apoenzyme, and the subsequent r...

Curves That Must Be Retraced

We exhibit a polynomial time computable plane curve Γ that has finite length, does not intersect itself, and is smooth except at one endpoint, but has the following property. For every computable parametrization f of Γ and every positive integer n, there is some positive-length subcurve of Γ that f retraces at least n times. In contrast, every computable curve of finite length that does not int...